This MIKAIA® University app note illustrates how to interactively train a new H&E segmentation AI with serial sections, without having to annotate tumor regions. Instead, an IHC epithelial marker (pan-cytokeratin...
Tag - IHC
Michaela Benz
Analyzing and Comparing Regions of Interest – “Divide by ROIs” Special
The “Divide by ROIs” feature in MIKAIA’s analysis apps enables users to compile statistics and enhance their understanding of variations in cell populations. This functionality allows for comparisons between user...
Grit Nickel
IHC Cell Detection App explained
The IHC Cell Detection App features a universal subcellular IHC cell AI that is compatible with a wide range of markers, tissues, and cell types. Our 23-minute video tutorial guides MIKAIA® step by step through the app...
Volker Bruns
MIKAIA IHC Cell Quantification AI Gallery
This gallery illustrates for a range of different tissue types and IHC markers the cell analysis quality of MIKAIA‘s IHC Cell Detection App. The app first unmixes the stain components, then uses an AI to delineate...
Quantify Histological Growth Pattern or Spatial Heterogeneity with the Grid Analysis App
Result of Grid Analysis App shows histological growth pattern and spatial heterogeneity
IHC Staining and Molecular Biomarkers
Cancer is a major cause of mortality worldwide, and the evaluation of predictive and prognostic markers is crucial in its pathologic assessment. Immunohistochemistry (IHC) is commonly used to evaluate biomarker status...
Nathalie Falk
MIKAIA: Differential IHC Cell Detection by ROI
This article is based on a our presentation “IHC Cell Analysis — More than just Cell Counting: A proposed Workflow” at the European Conference for Digital Pathology (ECDP) 2024 in Vilnius, Lithuania...
MIKAIA: Quantifying Perineural Invasion in Duplex IHC
This MIKAIA® App Note shows how to quantify tumor in proximity to nerve fibers (perineural invasion) in a IHC duplex-stained tissue section, where nerves appear red (antigen: S100) and tumor brown (antigen:...
TherVacB Vaccine: MIKAIA Used in Preclinical Immunotoxicity Study
The TherVacB project, led by Helmholtz Zentrum München, received a five-year funding within the Horizon 2020 program. With TherVacB, a therapeutic vaccine to cure Hepatitis B, the project’s aim is to provide a...
IHC Profiler in MIKAIA – Assessing New IHC Assay Using Multi-organ TMA
When designing a new immunohistochemistry (IHC) assay, a quantitative assessment of how it “responds” in different tissues of various organs is insightful and helps optimizing the assay in an objective way...
