Cancer is a major cause of mortality worldwide, and the evaluation of predictive and prognostic markers is crucial in its pathologic assessment. Immunohistochemistry (IHC) is commonly used to evaluate biomarker status...
Tag - IHC
Nathalie Falk
MIKAIA: Differential IHC Cell Detection by ROI
This article is based on a our presentation “IHC Cell Analysis — More than just Cell Counting: A proposed Workflow” at the European Conference for Digital Pathology (ECDP) 2024 in Vilnius, Lithuania...
Volker Bruns
MIKAIA: Quantifying Perineural Invasion in Duplex IHC
This MIKAIA® App Note shows how to quantify tumor in proximity to nerve fibers (perineural invasion) in a IHC duplex-stained tissue section, where nerves appear red (antigen: S100) and tumor brown (antigen:...
TherVacB Vaccine: MIKAIA Used in Preclinical Immunotoxicity Study
The TherVacB project, led by Helmholtz Zentrum München, received a five-year funding within the Horizon 2020 program. With TherVacB, a therapeutic vaccine to cure Hepatitis B, the project’s aim is to provide a...
IHC Profiler in MIKAIA – Assessing New IHC Assay Using Multi-organ TMA
When designing a new immunohistochemistry (IHC) assay, a quantitative assessment of how it “responds” in different tissues of various organs is insightful and helps optimizing the assay in an objective way...
MIKAIA Spatial Clustering App
Tumor cells dynamically interact with their microenvironment to stimulate cancer development, progression, and metastasis. To understand the biology of the tumor-immune interactions, it is essential to identify tumoral...
MIKAIA IHC Cell Detection App
MIKAIA® University Application Note: Immune cell infiltration in tumor micro environment (TME) List of other articles on analysis of IHC stains: Spatial clustering of IHC+ cells IHC Profiling ROI based differential...
