This article is based on a our presentation “IHC Cell Analysis — More than just Cell Counting: A proposed Workflow” at the European Conference for Digital Pathology (ECDP) 2024 in Vilnius, Lithuania...
Author - Volker Bruns
Volker Bruns
The Digital Pathologist’s Cockpit: Image Management Systems (IMS) – Free Download of List of IMSes
In conventional pathology, the pathologists mostly interacted with their LIS (lab information system). Synonyms are PIS (pathology information system) or LIMS (laboratory information & management system)...
List of Commercial Spatial Biology Instruments, Assays & Softwares
Spatial Biology is a big hype right now and a rapidly growing discipline, especially spatial proteomics and spatial transcriptomics. It is the intersection of anatomical pathology where the morphology of tissue is...
WSI and Annotation File Format I/O Support in MIKAIA
MIKAIA® supports various I/O formats, find out which ones. Importable whole-slide-image file formats Format / VendorCommentsOME-TIFFBrightfield and fluorescence. Z-stacks and timelines supported (mutually-exclusive). No...
MIKAIA: Quantifying Perineural Invasion in Duplex IHC
This MIKAIA® App Note shows how to quantify tumor in proximity to nerve fibers (perineural invasion) in a IHC duplex-stained tissue section, where nerves appear red (antigen: S100) and tumor brown (antigen:...
Digital Pathology AI Companies — List of Commercial AIs (CE-IVDR, FDA, RUO)
2022 and 2023 have been breakthrough years for AI in digital pathology. Many new startups, backed by lots of venture capital, as well as established vendors have released AIs cleared for clinical routine. As of today...
Annotation Concepts in MIKAIA for Whole-Slide-Images
The first step to creating a supervised Digital Pathology AI is to annotate whole-slide-images. MIKAIA® uses various annotation concepts. Working with MIKAIA® is easier when these annotation concepts are known and...
AI Will Survive: Integrating Artificial Intelligence in the Life Sciences
AI is on the rise in pretty much every scientific field (at least it feels that way). We talked to Nathalie Falk, one of the voices behind the MIKAIA University application notes, molecular biologist with a PhD in...
Grit Nickel
TherVacB Vaccine: MIKAIA Used in Preclinical Immunotoxicity Study
The TherVacB project, led by Helmholtz Zentrum München, received a five-year funding within the Horizon 2020 program. With TherVacB, a therapeutic vaccine to cure Hepatitis B, the project’s aim is to provide a...
IHC Profiler in MIKAIA – Assessing New IHC Assay Using Multi-organ TMA
When designing a new immunohistochemistry (IHC) assay, a quantitative assessment of how it “responds” in different tissues of various organs is insightful and helps optimizing the assay in an objective way...
