{"id":952,"date":"2023-11-06T09:16:46","date_gmt":"2023-11-06T08:16:46","guid":{"rendered":"https:\/\/websites.fraunhofer.de\/smart-sensing-insights\/?p=952"},"modified":"2025-10-29T21:54:19","modified_gmt":"2025-10-29T20:54:19","slug":"thervacb","status":"publish","type":"post","link":"https:\/\/websites.fraunhofer.de\/smart-sensing-insights\/thervacb\/","title":{"rendered":"TherVacB Vaccine: MIKAIA Used in Preclinical Immunotoxicity Study"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">The <a href=\"https:\/\/www.thervacb.eu\/\">TherVacB project<\/a>, led by <a href=\"https:\/\/www.helmholtz-munich.de\/\">Helmholtz Zentrum M\u00fcnchen<\/a>, received a five-year funding within the Horizon 2020 program. With TherVacB, a therapeutic vaccine to cure Hepatitis B, the project&#8217;s aim is to provide a novel and affordable curative treatment  for chronic hepatitis B patients: <\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">The mission of TherVacB is to overcome HBV-specific immune tolerance and to restore antiviral B-cell and T-cell responses by therapeutic vaccination to finally cure HBV.&nbsp;<\/p>\n<cite>https:\/\/www.thervacb.eu\/the-project\/<\/cite><\/blockquote>\n\n\n\n<p class=\"wp-block-paragraph\">In September 2023, results from a preclinical immunotoxicity study were presented by the project consortium at the <strong>20<sup>th<\/sup>&nbsp;European Congress of Toxicologic Pathology<\/strong> (ESTP23) in Basel, Switzerland. Here is the presented poster: <em>Pathohistological evaluation to exclude immunotoxic effects of the TherVacB vaccine in liver tissue \u2013 Results from an immunotoxicity GLP study using a transgenic AAV-HBV mouse model<\/em>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">ESTP23 Poster<\/h2>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-fill\"><a class=\"wp-block-button__link has-gridlove-highlight-bg-background-color has-background wp-element-button\" href=\"https:\/\/www.iis.fraunhofer.de\/de\/ff\/sse\/sse-blog\/TherVacB.html\">Download as PDF<\/a><\/div>\n<\/div>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"732\" src=\"https:\/\/websites.fraunhofer.de\/smart-sensing-insights\/wp-content\/uploads\/2023\/10\/ESTP-2023_Poster_TVB-Histology_A.-Hoffmann_20230925-1024x732.jpg\" alt=\"Poster &quot;Pathohistological evaluation to exclude immunotoxic effects of the TherVacB vaccine in liver tissue&quot;\" class=\"wp-image-973\" srcset=\"https:\/\/websites.fraunhofer.de\/smart-sensing-insights\/wp-content\/uploads\/2023\/10\/ESTP-2023_Poster_TVB-Histology_A.-Hoffmann_20230925-1024x732.jpg 1024w, https:\/\/websites.fraunhofer.de\/smart-sensing-insights\/wp-content\/uploads\/2023\/10\/ESTP-2023_Poster_TVB-Histology_A.-Hoffmann_20230925-300x214.jpg 300w, https:\/\/websites.fraunhofer.de\/smart-sensing-insights\/wp-content\/uploads\/2023\/10\/ESTP-2023_Poster_TVB-Histology_A.-Hoffmann_20230925-768x549.jpg 768w, https:\/\/websites.fraunhofer.de\/smart-sensing-insights\/wp-content\/uploads\/2023\/10\/ESTP-2023_Poster_TVB-Histology_A.-Hoffmann_20230925-370x264.jpg 370w, https:\/\/websites.fraunhofer.de\/smart-sensing-insights\/wp-content\/uploads\/2023\/10\/ESTP-2023_Poster_TVB-Histology_A.-Hoffmann_20230925-270x193.jpg 270w, https:\/\/websites.fraunhofer.de\/smart-sensing-insights\/wp-content\/uploads\/2023\/10\/ESTP-2023_Poster_TVB-Histology_A.-Hoffmann_20230925-570x407.jpg 570w, https:\/\/websites.fraunhofer.de\/smart-sensing-insights\/wp-content\/uploads\/2023\/10\/ESTP-2023_Poster_TVB-Histology_A.-Hoffmann_20230925-740x529.jpg 740w, https:\/\/websites.fraunhofer.de\/smart-sensing-insights\/wp-content\/uploads\/2023\/10\/ESTP-2023_Poster_TVB-Histology_A.-Hoffmann_20230925.jpg 1362w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">ESTP23 poster, &#8220;Pathohistological evaluation to exclude immunotoxic effects of the<br>TherVacB vaccine in liver tissue&#8221;, \u00a9 Fraunhofer IZI<\/figcaption><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\" style=\"font-size:19px\"><strong>Authors<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">A. Hoffmann<sup>1<\/sup>, S. Riemschneider<sup>1<\/sup>, K. Klose<sup>1<\/sup>, O. Antoniadou<sup>1<\/sup>, V. Bruns\u00b3, M. Kreuz<sup>1<\/sup>, A. Kosinska\u00b2, F. Thiele\u00b2, M. Wiegand\u00b2, U. Protzer\u00b2, and J. Lehmann<sup>1<\/sup><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><sup>1<\/sup> <strong>Fraunhofer Institute for Cell Therapy and Immunology (IZI<\/strong>)<br>Leipzig, Perlickstra\u00dfe 1, 04103 Leipzig<\/li>\n\n\n\n<li>\u00b2 <strong>Institute of Virology, Technical University of Munich, Helmholtz-Zentrum M\u00fcnchen<\/strong> <br>Munich, Trogerstra\u00dfe 30, 81675 M\u00fcnchen, Germany<\/li>\n\n\n\n<li>\u00b3 <strong>Fraunhofer Institute for Integrated Circuits (IIS)<\/strong><br>Erlangen, Am Wolfsmantel 33, 91058 Erlangen, Germany<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Batch T-cell quantification with MIKAIA<sup>\u00ae<\/sup><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The digital dataset comprised close to 300 whole-slide images (WSI):<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>~100 WSIs each for quantification of CD3+, CD4+ and CD8a+ T cells<\/li>\n\n\n\n<li>2 liver sections per scan<\/li>\n\n\n\n<li>Zeiss CZI format, 40x objective, scanned with Zeiss AxioScan<\/li>\n\n\n\n<li>2.5 TB image data in total<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">The <a href=\"https:\/\/websites.fraunhofer.de\/smart-sensing-insights\/mikaia-ihc-cell-detection-app\/\">MIKAIA<sup>\u00ae<\/sup> IHC Cell Detection App<\/a> was used to detect the liver tissue and number of DAB+ cells. The absolute amount and cells\/mm\u00b2 cell density was stated separately per liver section (2 per scan), utilizing the scan region extracted from the Zeiss CZI format. The analysis was performed in three batch jobs \u2013 one per marker. Each batch took ~2 hours to compute. The result is a folder each, that contains<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>per slide: \n<ul class=\"wp-block-list\">\n<li>MIKAIA<sup>\u00ae<\/sup> annotation overlay file (*.ano)<\/li>\n\n\n\n<li>shortcuts to the analyzed files <\/li>\n\n\n\n<li>low-resolution (~3000x3000px) PNGs with and without burnt-in markup<\/li>\n\n\n\n<li>CSV with quantitative outputs (area in \u00b5m\u00b2 per tissue, # contained DAB+ cells)<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>summary CSV file containing all rows from individual per-slide CSV files<\/li>\n\n\n\n<li>*.cfg file with used MIKAIA<sup>\u00ae<\/sup> app configuration parameters (loadable into MIKAIA<sup>\u00ae<\/sup>)<\/li>\n\n\n\n<li>*.micbat MIKAIA<sup>\u00ae<\/sup> batch-analysis file for repeating the batch-analysis on demand<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The TherVacB project, led by Helmholtz Zentrum M\u00fcnchen, received a five-year funding within the Horizon 2020 program. With TherVacB, a therapeutic vaccine to cure Hepatitis B, the project&#8217;s aim is to provide a novel and affordable curative treatment for chronic hepatitis B patients: The mission of TherVacB is to overcome HBV-specific immune tolerance and to [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":973,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,35],"tags":[87,7,30],"coauthors":[56],"class_list":["post-952","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-digital-pathology","category-life-science","tag-ihc","tag-mikaia","tag-publication"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>TherVacB Vaccine: MIKAIA Used in Preclinical Immunotoxicity Study - SMART SENSING insights<\/title>\n<meta name=\"description\" content=\"Use case for the MIKAIA IHC Cell Detection App: Read the poster on immunotoxic effects of the TherVacB vaccine in liver tissue.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/websites.fraunhofer.de\/smart-sensing-insights\/thervacb\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"TherVacB Vaccine: MIKAIA Used in Preclinical Immunotoxicity Study - 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