{"id":2195,"date":"2024-07-09T08:56:50","date_gmt":"2024-07-09T06:56:50","guid":{"rendered":"https:\/\/websites.fraunhofer.de\/smart-sensing-insights\/?p=2195"},"modified":"2025-10-29T21:54:04","modified_gmt":"2025-10-29T20:54:04","slug":"spatial-biology-vendor-list","status":"publish","type":"post","link":"https:\/\/websites.fraunhofer.de\/smart-sensing-insights\/spatial-biology-vendor-list\/","title":{"rendered":"List of Commercial Spatial Biology Instruments, Assays & Softwares"},"content":{"rendered":"\n

Spatial Biology is a big hype right now and a rapidly growing discipline, especially spatial proteomics and spatial transcriptomics. It is the intersection of anatomical pathology where the morphology of tissue is examined, and molecular pathology, where proteins, genes, or transcripts are analyzed.<\/p>\n\n\n\n

A more detailed introduction into Spatial Biology is available in our Spatial Biology 101<\/a> blog article.
If you are not a molecular biologist, we recommend reading our Molecular Biology 101 for Techies<\/a> article first.<\/p>\n\n\n\n

The following diagram explains the advantage of spatial transcriptomics<\/strong> over bulk sequencing<\/strong> and single-cell sequencing<\/strong>. <\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Spatial transcriptomics is likely the main discipline covered by the umbrella term “spatial biology”, the other one being “spatial proteomics”. Other areas such as metabolomics, lipidomics, glycomics, etc. are outside of this article’s scope. Vendors employ various technologies to generate spatial data. The technologies have different pros and cons and typically present trade-offs in this list of features: <\/p>\n\n\n\n

Scanning time<\/td>minutes \u2194 days<\/td><\/tr>
Resolution<\/td>sub-cellular \u2194 multiple cells<\/td><\/tr>
Field of View<\/td>mm \u2194 cm<\/td><\/tr>
Analytes<\/td>proteins, RNAs, metabolites<\/td><\/tr>
Panel size<\/td><10 genes \u2194 whole exome<\/td><\/tr>
Costs <\/td>instrument, consumables, maintenance<\/td><\/tr><\/tbody><\/table>
This figure gives an overview of the available technologies and locates commercial instruments on this technology map.
Technologies employed in spatial proteomics include Cyclic Restaining (seqIF), Multispectral Imaging (MSI), Mass Cytometry Imaging (MSI) such as Imaging Mass Cytometry by Time of Flight (CyToF), or Multiplexed Ion Beam Imaging (MIBI).
Technologies employed in spatial transcriptomics include In Situ Hybridization (FISH), In situ sequencing (ISS), pooled analysis of microdissected ROIs, and Microarrays (such as the popular Visium by 10x Genomics).<\/figcaption><\/figure>\n\n\n\n
\"\"<\/figure>\n\n\n\n

Free download of curated list of Spatial Biology solutions (instruments, softwares, assays …)<\/h2>\n\n\n\n

<\/p>\n\n\n\n

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download pdf
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Last updated 25.07.2024.
Don’t miss any updates by subscribing to our newsletter<\/a><\/p>\n<\/div>\n\n\n\n

<\/p>\n\n\n\n

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Also check out our other product lists:<\/p>\n<\/div>\n<\/div>\n\n\n\n

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IMS Vendors<\/a><\/div>\n\n\n\n
Digital Pathology AIs<\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n

<\/p>\n\n\n\n

Check out MIKAIA\u00ae<\/sup><\/a> : our image analysis multi-tool for Digital Pathology & Spatial Biology researchers.<\/p>\n","protected":false},"excerpt":{"rendered":"

Spatial Biology is a big hype right now and a rapidly growing discipline, especially spatial proteomics and spatial transcriptomics. It is the intersection of anatomical pathology where the morphology of tissue is examined, and molecular pathology, where proteins, genes, or transcripts are analyzed. A more detailed introduction into Spatial Biology is available in our Spatial […]<\/p>\n","protected":false},"author":2,"featured_media":2206,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[24],"tags":[7,85],"coauthors":[56],"class_list":["post-2195","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-spatial-biology","tag-mikaia","tag-vendor-list"],"yoast_head":"\nList of Commercial Spatial Biology Instruments, Assays & Softwares - SMART SENSING insights<\/title>\n<meta name=\"description\" content=\"Overview of technologies in spatial transcriptomics, proteomics and free download of a list of commercial instruments, assays and softwares.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/websites.fraunhofer.de\/smart-sensing-insights\/spatial-biology-vendor-list\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"List of Commercial Spatial Biology Instruments, Assays & Softwares - SMART SENSING insights\" \/>\n<meta property=\"og:description\" content=\"Overview of technologies in spatial transcriptomics, proteomics and free download of a list of commercial instruments, assays and softwares.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/websites.fraunhofer.de\/smart-sensing-insights\/spatial-biology-vendor-list\/\" \/>\n<meta property=\"og:site_name\" content=\"SMART SENSING insights\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/FraunhoferIIS\" \/>\n<meta property=\"article:published_time\" content=\"2024-07-09T06:56:50+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-10-29T20:54:04+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/websites.fraunhofer.de\/smart-sensing-insights\/wp-content\/uploads\/2024\/07\/spatial-biology-instruments.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"961\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Volker Bruns\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Volker Bruns\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/websites.fraunhofer.de\\\/smart-sensing-insights\\\/spatial-biology-vendor-list\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/websites.fraunhofer.de\\\/smart-sensing-insights\\\/spatial-biology-vendor-list\\\/\"},\"author\":{\"name\":\"Volker Bruns\",\"@id\":\"https:\\\/\\\/websites.fraunhofer.de\\\/smart-sensing-insights\\\/#\\\/schema\\\/person\\\/fd37d35c4d3576840cf0bc3f74eafb98\"},\"headline\":\"List of Commercial Spatial Biology Instruments, Assays & Softwares\",\"datePublished\":\"2024-07-09T06:56:50+00:00\",\"dateModified\":\"2025-10-29T20:54:04+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/websites.fraunhofer.de\\\/smart-sensing-insights\\\/spatial-biology-vendor-list\\\/\"},\"wordCount\":315,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/websites.fraunhofer.de\\\/smart-sensing-insights\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/websites.fraunhofer.de\\\/smart-sensing-insights\\\/spatial-biology-vendor-list\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/websites.fraunhofer.de\\\/smart-sensing-insights\\\/wp-content\\\/uploads\\\/2024\\\/07\\\/spatial-biology-instruments.jpg\",\"keywords\":[\"MIKAIA\u00ae\",\"Vendor List\"],\"articleSection\":[\"Spatial Biology\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/websites.fraunhofer.de\\\/smart-sensing-insights\\\/spatial-biology-vendor-list\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/websites.fraunhofer.de\\\/smart-sensing-insights\\\/spatial-biology-vendor-list\\\/\",\"url\":\"https:\\\/\\\/websites.fraunhofer.de\\\/smart-sensing-insights\\\/spatial-biology-vendor-list\\\/\",\"name\":\"List of Commercial Spatial Biology Instruments, Assays & Softwares - 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